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Daniel L. Hartl is Higgins Professor of Biology in the Department of Organismic and Evolutionary Biology at Harvard University. His research focuses on the molecular basis of evolutionary changes in genes and genomes. His approach is guided by the philosophy that progress in molecular evolution and progress in molecular biology often go hand in hand, and that studies of molecular evolution are usually enhanced when they take advantage of information about biological function and molecular mechanism. The Drosophila Genome Project originated in his laboratory with studies of chromosome evolution using large-fragment DNA clones. He pioneered the evolutionary theory of genetic polymorphism and divergence, and developed a novel Bayesian method to show that most amino acid replacements in Arabidopsis (an inbreeder) are deleterious whereas those in Drosophila (an outbreeder) are beneficial. Dr. Hartl was awarded his PhD by the University of Wisconsin, he did postdoctoral studies at the University of California in Berkeley, and he has been on the faculty of the University of Minnesota, Purdue University and Washington University Medical School in St. Louis. Dr. Hartl has been honored with the Samuel Weiner Outstanding Scholar Award and Medal, the Medal of the Stazione Zoologica Anton Dohrn, and is an elected member of the National Academy of Sciences and the American Academy of Arts and Sciences. He is also a Past President of the Genetics Society of America and the Society for Molecular Biology and Evolution.
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